
%0 Journal Article
%A Barlin, GB 
%A Davies, LP 
%A Davis, RA 
%A Harrison, PW 
%T Imidazo[1,2-b]pyridazines. XVII. Synthesis and Central Nervous System Activity of Some 6-(Alkylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines Containing Methoxy, Methylenedioxy and Methyl Substituents
%J Australian Journal of Chemistry
%D 1994/11/01
%V 47
%N 11
%P 2001-2012
%K 
%R https://doi.org/10.1071/CH9942001
%U https://www.publish.csiro.au/paper/CH9942001 
%X Syntheses are reported for 6-( methylthio, ethylthio, propylthio, substituted benzylthio and chloro )-3-( methoxy, unsubstituted and benzamidomethyl )-2-arylimidazo[1,2-b] pyridazines containing methoxy, methylenedioxy and methyl groups attached to phenyl substituents . In tests of the ability of these compounds to displace [3H]diazepam from rat brain membranes, 3-methoxy-6-(3&#8242;,4&#8242;-methylenedioxybenzylthio)-2- (3&#8242;,4&#8242;-methylenedioxyphenyl) imidazo [1,2-b] pyridazine (IC50 1 nM) bound most strongly; methylenedioxy groups were beneficial to activity whereas polymethoxy or dimethyl substituents were generally detrimental. 
