
TY  - JOUR
A1  - Barlin, GB 
A1  - Ireland, SJ 
A1  - Nguyen, TMT 
A1  - Kotecka, B 
A1  - Rieckmann, KH 
T1  - Potential Antimalarials. XXI. Mannich Base Derivatives of 4-[7-Chloro(and 7-trifluoromethyl)quinolin-4-ylamino]phenols
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1994
VL  - 47
IS  - 8
SP  - 1553
EP  - 1560
KW  - 
UR  - https://doi.org/10.1071/CH9941553 
N2  - Syntheses are reported for 4-(7-chloroquinolin-4-ylamino)-2,6-bis(piperidin-1-ylmethyl)phenol (2) and its 3-fluoro and 3-piperidinyl derivatives. Some mono-Mannich analogues with 2-fluoro, 2-t-butyl and 3-trifluoromethyl substituents have also been prepared. In tests for antimalarial activity against the FC-27 and K-1 isolates of Plasmodium falciparum in vitro, compound (2) proved to be the most active (IC50 6.3-12.5 nM). 
ER  -

