
%0 Journal Article
%A Barlin, GB 
%A Ireland, SJ 
%A Nguyen, TMT 
%A Kotecka, B 
%A Rieckmann, KH 
%T Potential Antimalarials. XXI. Mannich Base Derivatives of 4-[7-Chloro(and 7-trifluoromethyl)quinolin-4-ylamino]phenols
%J Australian Journal of Chemistry
%D 1994/08/01
%V 47
%N 8
%P 1553-1560
%K 
%R https://doi.org/10.1071/CH9941553
%U https://www.publish.csiro.au/paper/CH9941553 
%X Syntheses are reported for 4-(7-chloroquinolin-4-ylamino)-2,6-bis(piperidin-1-ylmethyl)phenol (2) and its 3-fluoro and 3-piperidinyl derivatives. Some mono-Mannich analogues with 2-fluoro, 2-t-butyl and 3-trifluoromethyl substituents have also been prepared. In tests for antimalarial activity against the FC-27 and K-1 isolates of Plasmodium falciparum in vitro, compound (2) proved to be the most active (IC50 6.3-12.5 nM). 
