
TY  - JOUR
A1  - Bawrlin, GB 
A1  - Ireland, SJ 
A1  - Nguyen, TMT 
A1  - Kotecka, B 
A1  - Rieckmann, KH 
T1  - Potential Antimalarials. XX. Mannich Base Derivatives of 2-[7-Chloroquinolin-4-ylamino and 7-Bromo(and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]-4-chloro(or 4- or 6-t-Butyl or 4- or 5-fluoro)phenols and 4(or 6)-t-Butyl-2-(7-trifluoromethylquinolin-4-ylamino)phenol
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1994
VL  - 47
IS  - 6
SP  - 1143
EP  - 1154
KW  - 
UR  - https://doi.org/10.1071/CH9941143 
N2  - Syntheses are reported for some mono- and di-Mannich base derivatives of 4-chloro-, 3- or 4-fluoro-, or 2- or 4-t-butyl-substituted 2-(7&#8242;-chloroquinolin-4&#8242;-ylamino)phenols and 2-[7&#8242;-bromo(and 7&#8242;-trifluoromethyl)-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino]phenols. In tests against the FC-27 isolate of Plasmodium falciparum, the most active compound was 2-(7&#8242;-chloroquinolin-4&#8242;-ylamino)-5-fluoro-4,6-bis(piperidin-1&#8242;-ylmethyl)phenol (16) with IC50 12.2 nM. 
ER  -

