
%0 Journal Article
%A Carroll, AR 
%A Bowden, BF 
%A Coll, JC 
%A Hockless, DCR 
%A Skelton, BW 
%A White, AH 
%T Studies of Australian Ascidians. IV. Mollamide, a Cytotoxic Cyclic Heptapeptide From the Compound Ascidian <I>Didemnum molle</I>
%J Australian Journal of Chemistry
%D 1994/01/01
%V 47
%N 1
%P 61-69
%K 
%R https://doi.org/10.1071/CH9940061
%U https://www.publish.csiro.au/paper/CH9940061 
%X A new cytotoxic cyclic heptapeptide, mollamide, has been isolated from the compound ascidian Didemnum molle. The structure of mollamide was initially deduced from one-dimensional and two-dimensional n.m.r . experiments at 300 MHz. The structure was confirmed by an X-ray crystallographic study, which showed the relative stereochemistry of the cyclic peptide. Hydrolysis of mollamide , and characterization of the amino acids by derivatization with N&#945; -(5-fluoro-2,4-dinitrophenyl)-L- alaninamide (FDAA; Marfey's reagent) gave the absolute stereochemistry; all constituent amino acids were the L-isomers. Cytotoxicity data are reported. 
