
TY  - JOUR
A1  - Barlin, GB 
A1  - Ireland, SJ 
A1  - Jiravinyu, C 
A1  - Nguyen, TMT 
A1  - Kotecka, B 
A1  - Rieckmann, KH 
T1  - Potential Antimalarials. XIX. Syntheses and Testing of &#945;-(Piperidin-2-yl)-&#945;-(7&#8242;-trifluoromethylquinolin-4&#8242;-yl)methanol and &#945;-(7-Bromo-1,5-naphthyridin-4-yl)-&#945;-(piperidin-2&#8242;-yl)methanol
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1993
VL  - 46
IS  - 11
SP  - 1695
EP  - 1703
KW  - 
UR  - https://doi.org/10.1071/CH9931695 
N2  - The synthesis of the mefloquine analogue &#945;-(piperidin-2-yl)-&#945;-(7&#8242;-trifluoromethylquinolin-4&#8242;-yl)methanol (1) from 4-bromo-7-trifluoromethylquinoline and N-(hex-5-enyl) phthalimide through N-{4-[3&#8242;-(7&#8243;-trifluoromethylquinolin-4&#8243;-yl)oxiran-2&#8242;-yl]butyl} phthalimide 1&#8242;-oxide is reported. &#945;-(7-Bromo-1,5-naphthyridin-4-yl)-&#945;-(piperidin-2&#8242;-yl)methanol (2) was prepared by similar procedures. In tests against the K-1 isolate of Plasmodium falciparum, compound (1) proved the more active (IC50 99 nM ). 
ER  -

