
%0 Journal Article
%A Barlin, GB 
%A Ireland, SJ 
%A Jiravinyu, C 
%A Nguyen, TMT 
%A Kotecka, B 
%A Rieckmann, KH 
%T Potential Antimalarials. XIX. Syntheses and Testing of &#945;-(Piperidin-2-yl)-&#945;-(7&#8242;-trifluoromethylquinolin-4&#8242;-yl)methanol and &#945;-(7-Bromo-1,5-naphthyridin-4-yl)-&#945;-(piperidin-2&#8242;-yl)methanol
%J Australian Journal of Chemistry
%D 1993/11/01
%V 46
%N 11
%P 1695-1703
%K 
%R https://doi.org/10.1071/CH9931695
%U https://www.publish.csiro.au/paper/CH9931695 
%X The synthesis of the mefloquine analogue &#945;-(piperidin-2-yl)-&#945;-(7&#8242;-trifluoromethylquinolin-4&#8242;-yl)methanol (1) from 4-bromo-7-trifluoromethylquinoline and N-(hex-5-enyl) phthalimide through N-{4-[3&#8242;-(7&#8243;-trifluoromethylquinolin-4&#8243;-yl)oxiran-2&#8242;-yl]butyl} phthalimide 1&#8242;-oxide is reported. &#945;-(7-Bromo-1,5-naphthyridin-4-yl)-&#945;-(piperidin-2&#8242;-yl)methanol (2) was prepared by similar procedures. In tests against the K-1 isolate of Plasmodium falciparum, compound (1) proved the more active (IC50 99 nM ). 
