
TY  - JOUR
A1  - Barlin, GB 
A1  - Ireland, SJ 
A1  - Nguyen, TMT 
A1  - Kotecka, B 
A1  - Rieckmann, KH 
T1  - Potential Antimalarials. XVIII. Some Mono- and Di-Mannich Bases of 3-[7-Chloro(and trifluoromethyl)quinolin-4-ylamino]phenol
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1993
VL  - 46
IS  - 11
SP  - 1685
EP  - 1693
KW  - 
UR  - https://doi.org/10.1071/CH9931685 
N2  - Syntheses are reported for mono- and di-Mannich base derivatives of 3-[7-chloro(and trifluoro-methyl)quinolin-4-ylamino]phenols by Mannich reaction on 3-[7-chloro(and trifluoromethyl )-quinolin-4-ylamino]phenols or by condensation of Mannich base derivatives of 3-aminophenol, prepared from 3-nitrophenol, with the appropriate 4-chloroquinoline. The antimalarial activity of 3-(7&#8242;-chloroquinolin-4&#8242;-ylamino)-2,6-bis[ pyrrolidin-1&#8243;-ylmethyl -(or piperidin-1&#8243;-ylmethyl)]phenol against the FC-27 isolate of Plasmodium falciparum was comparable to that of chloroquine, and it was not significantly diminished in tests against the chloroquine -resistant K-1 isolate. 
ER  -

