
%0 Journal Article
%A Brown, SE 
%A Coates, JH 
%A Coghlan, DR 
%A Easton, CJ 
%A Vaneyk, SJ 
%A Janowski, W 
%A Lepore, A 
%A Lincoln, SF 
%A Luo, Y 
%A May, BL 
%A Schiesser, DS 
%A Wang, P 
%A Williams, ML 
%T Synthesis and Properties of 6<sup>A</sup>-Amino-6<sup>A</sup>-deoxy-&#945; and &#946;-cyclodextrin
%J Australian Journal of Chemistry
%D 1993/06/01
%V 46
%N 6
%P 953-958
%K 
%R https://doi.org/10.1071/CH9930953
%U https://www.publish.csiro.au/paper/CH9930953 
%X The monotosylates obtained by treatment of &#945;- and &#946;- cyclodextrin with p- methylbenzenesulfonyl chloride reacted with ammonia to give the title compounds. These amines are of unusually low basicity , with pKa values of 8.70 and 8.72, respectively. In water at 25&#176;, the hydrochloride salt of the amine derived from &#946;- cyclodextrin is approximately 40 times more soluble than &#946;-cyclodextrin and, through complexation, the salt increases the solubility of Nabumetone over 800 times. 
