
%0 Journal Article
%A Deady, LW 
%A Quazi, NH 
%T Synthesis of Pyrazino[2,3-c]isoquinolinecarboxylic Acids and Related Compounds
%J Australian Journal of Chemistry
%D 1992/12/01
%V 45
%N 12
%P 2083-2087
%K 
%R https://doi.org/10.1071/CH9922083
%U https://www.publish.csiro.au/paper/CH9922083 
%X 1-Methylisoquinoline-3,4-diamine has been synthesized and condensed with &#945;-dicarbonyl compounds to give the fused pyrazine ring. Oxidation of methyl groups gives the 3- and 6-carboxylic acids. Nitration occurs in the benzenoid ring to give the single 10-nitro product, and formation of an unusual 6-trinitromethyl compound is also reported. 
