
%0 Journal Article
%A Evans, RF 
%A Savage, GP 
%T Methylation of Some Deprotonated Sterically Hindered Pyrimidin-4-ols
%J Australian Journal of Chemistry
%D 1992/02/01
%V 45
%N 2
%P 463-468
%K 
%R https://doi.org/10.1071/CH9920463
%U https://www.publish.csiro.au/paper/CH9920463 
%X Anions derived from t-butyl-substituted pyrimidin-4-ols were methylated with iodomethane . The site of methylation was determined by proton-coupled 13C n.m.r. and the relative proportions of isomers were determined by 1H n.m.r. A t-butyl substituent  ortho to a ring nitrogen markedly reduced the propensity for methylation at that nitrogen to the point where O-methylation, uncommon under these conditions, was observed. 
