
TY  - JOUR
A1  - Bulock, JD 
A1  - Clough, LE 
T1  - Sirodesmin Biosynthesis
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1992
VL  - 45
IS  - 1
SP  - 39
EP  - 45
KW  - 
UR  - https://doi.org/10.1071/CH9920039 
N2  - Using DL-[3,5-3H,U-14C]tyrosine it is shown that in the biosynthesis of sirodesmins all nine carbon atoms of tyrosine are incorporated into the rearranged structure. Using [13C21acetate it is confirmed that the biosynthesis proceeds by way of a type of Claisen rearrangement of an O-(3,3-dimethylallyl)tyrosine derivative, and the chirality of this rearrangement is established. The order and stereochemical implications of other steps in the biosynthesis are considered. 
ER  -

