
%0 Journal Article
%A Bu, Xianyong 
%A Deady, Leslie W. 
%A Denny, William A. 
%T Synthesis and Cytotoxic Activity of <emph type="2">N</emph>-[2-(Dimethylamino)ethyl] Carboxamide Derivatives of Benzofuro[2,3-<emph type="2">b</emph>]quinoline, 6<emph type="2">H</emph>-Quinindoline, Indeno[2,1-<emph type="2">b</emph>]quinoline and [1]Benzothieno[2,3-<emph type="2">b</emph>]quinoline
%J Australian Journal of Chemistry
%D 2000/05/11
%V 53
%N 2
%P 143-147
%K Antitumour; cytotoxic; synthesis; carboxamides; quinoline.
%R https://doi.org/10.1071/CH99166
%U https://www.publish.csiro.au/paper/CH99166 
%X The acid precursors of the title compounds were prepared from methyl 2-amino-3-formylbenzoate (3), by Friedl&#196;nder synthesis with o-methoxy- and o-nitro-phenylacetic acids, phenylpyruvic acid and benzo&#91;b&#93;thiophen-2-one, respectively. Except for the last example, cyclization of an initial 3-arylquinoline derivative was then required to give the tetracycle. Growth inhibition properties of the carboxamides in a series of cancer cell lines were measured for comparison with previous data for an isomeric series. In all cases, the present set were found to be less active. 
