
TY  - JOUR
A1  - Arbain, D 
A1  - Langley, J 
A1  - Picker, K 
A1  - Taylor, WC 
T1  - The Determination of Chirality of N-Methyl- and N,N-Dimethyl-phenylalanine by G.L.C.
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1991
VL  - 44
IS  - 6
SP  - 887
EP  - 890
KW  - 
UR  - https://doi.org/10.1071/CH9910887 
N2  - The chirality of N- methylphenylalanine enantiomers can be determined on a micro scale by g.l.c . of N-pentafluoropropionyl amino acid isopropyl esters on a Chirasil -L-Val capillary column. N,N- Dimethylphenylalanine enantiomers cannot be similarly derivatized and cannot be separated. However, prior treatment with ethyl chloroformate followed by acid hydrolysis effects demethylation to the N-methyl analogues which can then be derivatized for g.l.c . Contrary to literature reports N-methylphenylalanine can be prepared by reductive alkylation of phenylalanine. 
ER  -

