
TY  - JOUR
A1  - Prager, RH 
A1  - Tsopelas, C 
A1  - Heisler, T 
T1  - A Simple Synthesis of Amphimedine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1991
VL  - 44
IS  - 2
SP  - 277
EP  - 285
KW  - 
UR  - https://doi.org/10.1071/CH9910277 
N2  - The marine alkaloid amphimedine has been synthesized by a short sequence of reactions commencing from the known indenopyridinedione (2). Reaction with 4-pyridyllithium, followed by hydrazoic acid treatment, gave 5-(4-pyridyl)-3,6-phenanthrolin-4(3H)-one (12) which was converted into the chlorophenanthroline. The methyl-substituted fluorosulfonate salt of this compound was specifically oxidized by alkaline ferricyanide. Conversion of the pyridone into the nitrile gave the precursor which was cyclized to amphimedine by polyphosphoric acid. 
ER  -

