
TY  - JOUR
A1  - Banwell, Martin G. 
A1  - Flynn, Bernard L. 
A1  - Hamel, Ernest 
A1  - Willis, Anthony C. 
T1  - Synthesis, X-Ray Crystal Structure and Tubulin- Binding Properties of a Benzofuran Analogue of the Potent Cytotoxic Agent Combretastatin A4
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1999
VL  - 52
IS  - 8
SP  - 767
EP  - 774
KW  - 
UR  - https://doi.org/10.1071/CH99022 
N2  - The benzofuran (4), a ring-fused analogue of the potent antimitotic agent combretastatin A4 (1), has been prepared by a convergent route involving 5-endo-dig iodocyclization of o-hydroxytolan (5) as the key step. Compound (4), which has been characterized crystallographically as well as spectroscopically, is inactive as a tubulin-binding agent. 
ER  -

