
%0 Journal Article
%A Banwell, Martin G. 
%A Flynn, Bernard L. 
%A Hamel, Ernest 
%A Willis, Anthony C. 
%T Synthesis, X-Ray Crystal Structure and Tubulin- Binding Properties of a Benzofuran Analogue of the Potent Cytotoxic Agent Combretastatin A4
%J Australian Journal of Chemistry
%D 1999/08/27
%V 52
%N 8
%P 767-774
%K 
%R https://doi.org/10.1071/CH99022
%U https://www.publish.csiro.au/paper/CH99022 
%X The benzofuran (4), a ring-fused analogue of the potent antimitotic agent combretastatin A4 (1), has been prepared by a convergent route involving 5-endo-dig iodocyclization of o-hydroxytolan (5) as the key step. Compound (4), which has been characterized crystallographically as well as spectroscopically, is inactive as a tubulin-binding agent. 
