
TY  - JOUR
A1  - Allan, RD 
A1  - Apostopoulos, C 
A1  - Richardson, JA 
T1  - 2-Imino-1,3,4-thiadiazole Derivatives of GABA as GABA<sub>A</sub> Antagonists
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 10
SP  - 1767
EP  - 1772
KW  - 
UR  - https://doi.org/10.1071/CH9901767 
N2  - New heterocyclic derivatives of GABA, with a GABA moiety on the 3 position of a 2-imino-1,3,4-thiadiazole ring, have been readily prepared by alkylation of 2-amino-5-aryl-1,3,4-thiadiazoles in dimethylformamide. They are active as GABAA antagonists, inhibiting the action of GABA on the guinea-pig ileum about 5 times less potently than bicuculline. 
ER  -

