
%0 Journal Article
%A Allan, RD 
%A Apostopoulos, C 
%A Richardson, JA 
%T 2-Imino-1,3,4-thiadiazole Derivatives of GABA as GABA<sub>A</sub> Antagonists
%J Australian Journal of Chemistry
%D 1990/10/01
%V 43
%N 10
%P 1767-1772
%K 
%R https://doi.org/10.1071/CH9901767
%U https://www.publish.csiro.au/paper/CH9901767 
%X New heterocyclic derivatives of GABA, with a GABA moiety on the 3 position of a 2-imino-1,3,4-thiadiazole ring, have been readily prepared by alkylation of 2-amino-5-aryl-1,3,4-thiadiazoles in dimethylformamide. They are active as GABAA antagonists, inhibiting the action of GABA on the guinea-pig ileum about 5 times less potently than bicuculline. 
