
TY  - JOUR
A1  - Barlin, GB 
A1  - Jiravinyu, C 
T1  - Potential Antimalarials. X. Di-Mannich Bases of 4-(7'-Trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and N-(4'-Diethylamino-1'-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 7
SP  - 1175
EP  - 1181
KW  - 
UR  - https://doi.org/10.1071/CH9901175 
N2  - The syntheses of some di-Mannich bases derived from 4-(7&#8242;-trifluoromethyl-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino) phenol and of N-(4&#8242;-diethylamino-11&#8242;-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine from 3-chloro-5-trifluoromethylpyridine via4-chloro-7- trifluoromethyl-1,5-naphthyridine are described. In tests in vitro against the FCQ-27 strain of Plasmodium falciparum these compounds were slightly less active than their 7-bromo analogues. 
ER  -

