
TY  - JOUR
A1  - Moloney, GP 
A1  - Craik, DJ 
A1  - Iskander, MN 
A1  - Munro, SLA 
T1  - <sup>1</sup>H-N.M.R. and Theoretical Studies of the Conformation of the Antibiotic Lincomycin
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 3
SP  - 535
EP  - 548
KW  - 
UR  - https://doi.org/10.1071/CH9900535 
N2  - One- and two-dimensional 1H n.m.r. spectra of the amino glycoside antibiotic lincomycin have been measured and analysed. One-dimensional n.m.r. techniques applied included selective decoupling, resolution enhancement, and n.O.e. difference experiments. Two-dimensional n.m.r. techniques included chemical shift correlated spectroscopy (COSY) and n.O.e. spectroscopy (NOESY) experiments. A theoretical conformational analysis of the side chain of the sugar moiety has also been done by using a simplified potential energy program. Together, the theoretical and experimental (coupling constant and n.O.e.) data have allowed the conformation of lincomycin to be determined. 
ER  -

