
%0 Journal Article
%A Maclaren, JA 
%T &#946;-Carboline-3-carboxylic Acid (9H-Pyrido[3,4-b]indole-3-carboxylic Acid) and Related Compounds
%J Australian Journal of Chemistry
%D 1989/06/01
%V 42
%N 6
%P 813-821
%K 
%R https://doi.org/10.1071/CH9890813
%U https://www.publish.csiro.au/paper/CH9890813 
%X The synthesis of &#946;-carboline-3-carboxylic acid and its esters (4) by oxidation of the corresponding 1,2,3,4-tetrahydro derivatives (2) or of the 3,4-dihydro derivatives (3) has been studied. A novel synthesis of the esters (3) [and hence of (4)] has been achieved in high yield by cyclization and elimination from the enamine (5). The relative inhibition of binding of a benzodiazepine to rat brain membranes by the esters (2)-(4) has been determined. 
