
TY  - JOUR
A1  - Janowski, WK 
A1  - Prager, RH 
T1  - Potential GABA<sub>B</sub> Receptor Antagonists. II. Synthesis of 1-[2-Amino-1-(4-chlorophenyl)ethyl]-3-oxo-1,3-dihydroisobenzofuran-1-carboxylic Acid
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1989
VL  - 42
IS  - 5
SP  - 731
EP  - 736
KW  - 
UR  - https://doi.org/10.1071/CH9890731 
N2  - Michael addition of methyl 3-oxo-1,3-dihydroisobenzofuran-1-carboxylate to nitrostyrenes is catalysed by amine bases. In non-polar solvents, the use of both enantiomers of &#968;-ephedrine as base (0.1 equiv.) leads to both enantiomers , respectively, of a single diastereoisomer. When the reaction mixture is heated, the reaction is neither diastereoselective nor enantioselective. The products have been converted into the potential GABAB analogue 1-[2-amino-1-(4-chlorophenyl )ethyl]-3-oxo-1,3-dihydroisobenzofuran-1-carboxylic acid. 
ER  -

