
TY  - JOUR
A1  - Dawson, RM 
A1  - Godfrey, IM 
A1  - Hogg, RW 
A1  - Knox, JR 
T1  - Synthetic Routes to Some Isotopically Labeled Intermediates for Diterpenoid Biosynthesis
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1989
VL  - 42
IS  - 4
SP  - 561
EP  - 579
KW  - 
UR  - https://doi.org/10.1071/CH9890561 
N2  - The exo-15-hydrogen of ent-kaurene can be exchanged through a reversible ene reaction in a convenient and efficient procedure which has the potential for giving high specific activity 3H-labelling. Copalol, the (Z)-double bond stereoisomer, and the allylic alcohol isomers ent-manool and ent-epimanool have been obtained through divergent synthetic pathways involving a 15,16-bisnor ketone intermediate. These pathways have also allowed the four compounds to be obtained with 14C-labelling. A method, involving a Wittig reaction to form a vinyl bromide intermediate, has been developed for obtaining copalol, as the trityl ether derivative, with stereospecific isotopic labelling of one or the other of the hydrogens of the exocyclic methylene group. 
ER  -

