
TY  - JOUR
A1  - Pert, DJ 
A1  - Ridley, DD 
T1  - Preparations of 2,4-Disubstituted Oestradiols
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1989
VL  - 42
IS  - 3
SP  - 421
EP  - 432
KW  - 
UR  - https://doi.org/10.1071/CH9890421 
N2  - 2,4-Dibromoestra-1,3,S(10)-triene-3,17 &#946;- diol 3-(2'-hydroxyethyl) ether (8) undergoes reaction with copper(11) chloride/sodium methoxide to afford a 4-bromo [2,3]- dioxan derivative (9) as the major product together with a minor amount of a 2-bromo [3,4]- dioxan derivative (10). These compounds were used to prepare a number of 2,4-disubstituted oestradiol derivatives.   Alternative routes to other 2,4-disubstituted oestradiols are described. 
ER  -

