
%0 Journal Article
%A Pert, DJ 
%A Ridley, DD 
%T Preparations of 2,4-Disubstituted Oestradiols
%J Australian Journal of Chemistry
%D 1989/03/01
%V 42
%N 3
%P 421-432
%K 
%R https://doi.org/10.1071/CH9890421
%U https://www.publish.csiro.au/paper/CH9890421 
%X 2,4-Dibromoestra-1,3,S(10)-triene-3,17 &#946;- diol 3-(2'-hydroxyethyl) ether (8) undergoes reaction with copper(11) chloride/sodium methoxide to afford a 4-bromo [2,3]- dioxan derivative (9) as the major product together with a minor amount of a 2-bromo [3,4]- dioxan derivative (10). These compounds were used to prepare a number of 2,4-disubstituted oestradiol derivatives.   Alternative routes to other 2,4-disubstituted oestradiols are described. 
