
TY  - JOUR
A1  - Barlin, GB 
A1  - Davies, LP 
A1  - Ngu, MML 
T1  - Imidazo[1,2-b]pyridazines. IV. Syntheses and Central Nervous System Activities of Some 3-Methoxy-6-phenoxy(Substituted Phenoxy and Naphthyloxy)-2-phenylimidazo[1,2-b]pyridazines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1988
VL  - 41
IS  - 11
SP  - 1735
EP  - 1742
KW  - 
UR  - https://doi.org/10.1071/CH9881735 
N2  - Syntheses are reported for some 3-methoxy-6-phenoxy(substituted phenoxy and naphthyloxy )-2-phenylimidazo[1,2-b] pyridazines; they were made in order to study their possible pharmacological activity in the mammalian central and peripheral nervous system.  In initial biological screens to detect compounds with potential activity at receptors for the benzodiazepine class of drugs, the most active compounds were 3-methoxy-6-(2&#8242;-methylthiophenoxy)- and 6-(2&#8242;-dimethylaminophenoxy )-3-methoxy-2-phenylimidazo[1,2-b] pyridazine. Their respective IC50 values for displacement of 3H-diazepam (IC50 for unlabelled diazepam, 4.2 nM ) from rat brain plasma membranes (measured in the presence of 100 &#956;M GABA) were 112 and 149 nM. 
ER  -

