
%0 Journal Article
%A Waring, P 
%T The Synthesis of 6-Aminomethyl-5,6,7,8-Tetrahydropterin
%J Australian Journal of Chemistry
%D 1988/05/01
%V 41
%N 5
%P 667-676
%K 
%R https://doi.org/10.1071/CH9880667
%U https://www.publish.csiro.au/paper/CH9880667 
%X 6-Aminomethyl-5,6,7,8-tetrahydropterin has been prepared by reduction of 2-acetamido-6-cyanopteridin-4(3H)-one* to 2-acetamido-6-aminomethyl- 5,6,7,8-tetrahydropteridin-4(3H)-one followed by acid hydrolysis. The hitherto undescribed 6-cyanopterin was prepared by careful hydrolysis of the 2-acetamido compound prepared by dehydration of the oxime derived from 2-acetamido-6-formylpteridin-4(3H)-one. The latter was prepared by selenium dioxide oxidation of the methyl compound. Oxidation of 6-aminomethyl-5,6,7,8-tetrahydropterin at neutral pH appears to proceed with significant side-chain loss in Tris buffer but not in phosphate buffer. 
