
%0 Journal Article
%A Black, DS 
%A Chaichit, N 
%A Gatehouse, BM 
%A Moss, GI 
%T Metal Template Reactions. XXV. N-Acyl Isatin Precursors for the Synthesis of Malonamido Macrocyclic Metal Complexes
%J Australian Journal of Chemistry
%D 1987/10/01
%V 40
%N 10
%P 1745-1754
%K 
%R https://doi.org/10.1071/CH9871745
%U https://www.publish.csiro.au/paper/CH9871745 
%X Reaction of sodium isatide with dimethylmalonyl dichloride yielded the oxazinoindole (6) rather than the expected product (4). The glyoxylamide (8), which served as a precursor to the macrocyclic complex (15), was therefore prepared by a sequence involving compounds (9), (10) and (7). Such a route makes use of the reactivity of N-acyl isatins and the protecting capacity of the benzyloxycarbonyl group. The structure of compound (6) was established by X-ray crystallography. 
