
TY  - JOUR
A1  - Pert, DJ 
A1  - Ridley, DD 
T1  - An Alternative Route to 2-Bromo-Estradiols and 2-Iodo-Estradiols From Estradiol
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1987
VL  - 40
IS  - 2
SP  - 303
EP  - 309
KW  - 
UR  - https://doi.org/10.1071/CH9870303 
N2  - Through careful choice of reaction conditions, alkylation of estradiol with chloromethyl methyl ether may yield either the 3,17&#946;-bis(methoxymethy1) ether or the 3-methoxymethyl ether derivative. Treatment of either of these protected estradiols with s- butyllithium, then with trimethylsilyl chloride affords, regioselectively, the 2-trimethylsilyl derivatives which can conveniently be converted into 2-bromo-or 2-iodo-estradiol. 
ER  -

