
%0 Journal Article
%A Pert, DJ 
%A Ridley, DD 
%T An Alternative Route to 2-Bromo-Estradiols and 2-Iodo-Estradiols From Estradiol
%J Australian Journal of Chemistry
%D 1987/02/01
%V 40
%N 2
%P 303-309
%K 
%R https://doi.org/10.1071/CH9870303
%U https://www.publish.csiro.au/paper/CH9870303 
%X Through careful choice of reaction conditions, alkylation of estradiol with chloromethyl methyl ether may yield either the 3,17&#946;-bis(methoxymethy1) ether or the 3-methoxymethyl ether derivative. Treatment of either of these protected estradiols with s- butyllithium, then with trimethylsilyl chloride affords, regioselectively, the 2-trimethylsilyl derivatives which can conveniently be converted into 2-bromo-or 2-iodo-estradiol. 
