
TY  - JOUR
A1  - Allan, RD 
A1  - Fong, J 
T1  - Synthesis of Analogs of <sc>GABA</sc> .15. Preparation and Resolution of Some Potent Cyclopentene and Cyclopentane Derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1986
VL  - 39
IS  - 6
SP  - 855
EP  - 864
KW  - 
UR  - https://doi.org/10.1071/CH9860855 
N2  - A series of cyclopentene and cyclopentane analogues of GABA has been prepared utilizing a thermal cis -trans isomerization of the phthalimido &#946;,&#947; -unsaturated acid (10) as the key step to obtain trans-4- aminocyclopent-2-ene-1-carboxylic acid (7). Resolution of some of the potent GABA analogues, in particular (+)-(4S)- and (-)-(4R)-4- aminocyclopent-1-ene-1-carboxylic acid (5), has been achieved by crystallization of isopropylideneribonolactone esters or pantolactone esters of the phthalimido -protected intermediates. 
ER  -

