
%0 Journal Article
%A Deady, LW 
%A Werden, DM 
%T Nucleophilic-Substitution Reactions in Benzo[C][1,8]Naphthyridines
%J Australian Journal of Chemistry
%D 1986/04/01
%V 39
%N 4
%P 667-675
%K 
%R https://doi.org/10.1071/CH9860667
%U https://www.publish.csiro.au/paper/CH9860667 
%X The reactions of 1-chloro-3-methyl-6-(p- methylphenoxy ) benzo [c][1,8] naphthyridine with a variety of nucleophiles are reported. The relative reactivity of the 1- and 6-positions depends on the nucleophile and reaction conditions. Anilines, and alkyl and aryl thioxides react at position 1, alkylamines and alkoxide at position 6, and acidified alcohol at both 1 and 6. Some possible reasons for these positional reactivities are discussed. 
