
TY  - JOUR
A1  - Barlin, G 
A1  - Tan, W 
T1  - Potential Antimalarials. IV. 4-[7'-Bromo(and Chloro)-1&#8242;,5&#8242;-Naphthyridin-4&#8242;-Ylamino]Phenols and N<sup>4</sup>-Substituted 7-Chloro-1,5-Naphthyridin-4-Amines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1985
VL  - 38
IS  - 6
SP  - 905
EP  - 911
KW  - 
UR  - https://doi.org/10.1071/CH9850905 
N2  - A series of nine mono- and di-Mannich bases, for example 4-(7&#8242;-bromo-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino)-2,6-bis( dimethylaminomethyl )phenol derived from 4-(7&#8242;-bromo-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino)phenol and several other N4-substituted 7-bromo- and 7-chloro-1,5-naphthyridin-4- amines have been prepared. &#8242;All these compounds showed significant antimalarial activity when injected intraperitoneally in a single dose of 100-200 mg/kg to mice infected with Plasmodium vinckei vinckei. The di-Mannich bases appeared to be the most potent and effective in parasite control; however, no deaths were observed in infected mice treated with the mono- Mannich compounds. 
ER  -

