
TY  - JOUR
A1  - Barlin, GB 
A1  - Tan, W 
T1  - Potential Antimalarials. III. <i>N</i><sup>4</sup>-Substituted 7-Bromo-1,5-naphthyridin-4-amines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1985
VL  - 38
IS  - 3
SP  - 459
EP  - 465
KW  - 
UR  - https://doi.org/10.1071/CH9850459 
N2  - A series of new N4-substituted 7-bromo-1,5-naphthyridin-4-amines has been prepared from nicotinic acid through 3-bromo-8-chloro- 1,5- naphthyridine by nucleophilic replacement of the 8-chloro substituent with appropriate amines. Several of these compounds, namely 7-bromo-N- (4&#8242;-diethylamino-1&#8242;-methylbutyl)-1,5-naphthy-ridin-4-amine (&#8242;5-azabromoquine'), 4-(7&#8242;-bromo-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino)-2-(diethylamino-methyl)phenol and 7-bromo-N-(2&#8242;-diethylaminoethyl)-1,5- naphthyridin-4-amine showed significant antimalarial acivity. Apparent cures were effected when these test chemicals were injected intra-peritoneally in a single dose of 200 mg/kg to mice infected with Plasmodium vinckei vinckei. 
ER  -

