
TY  - JOUR
A1  - Becker, AMRRW 
T1  - 3-Amino-5-hydroxybenzoic acid in antibiotic biosynthesis. VIII. Synthesis of chlorinated analogues
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1984
VL  - 37
IS  - 10
SP  - 2103
EP  - 2109
KW  - 
UR  - https://doi.org/10.1071/CH9842103 
N2  - The three isomeric ring monochlorinated derivatives of 3-amino-5-hydroxybenzoic acid (1), required for studies of the biosynthesis and synthesis of several important classes of antibiotics, are prepared from methyl 3-amino-5-hydroxybenzoate (5). N-Chlorosuccinimide selectively monochlorinates the 2- and 6-positions of this substrate, whilst perchlorination followed by hydrolysis and regiospecific protodechlorination at the 2- and 6-positions affords the 4-chloro acid. 
ER  -

