
TY  - JOUR
A1  - Brown, DJ 
A1  - Lan, S 
A1  - Mori, K 
T1  - Heterocyclic amplifiers of phleomycin. IV. Pyrimidinylpurines, phenylpyrimidines and related systems with basic side chains
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1984
VL  - 37
IS  - 10
SP  - 2093
EP  - 2101
KW  - 
UR  - https://doi.org/10.1071/CH9842093 
N2  - Syntheses of 4,5,6-triamino-2,4'-bipyrimidines and subsequent conversions into 6-amino-2-pyrimidinylpurine-8-thiones, and their S-dimethylaminoethyl derivatives, are described; routes to a series of cyclohexyl- and piperidino-pyrimidines bearing a sulfur-linked side chain, as well as to phenyl- and methyl-pyrimidines bearing two such side chains, are also described. As amplifiers of phleomycin in a bacterial screen, the above purines proved poor, the cyclohexyl- and piperidinopyrimidines showed medium activities, and the phenylpyrimidines with two side chains (but not the analogous methylpyrimidines) exhibited very high activities. 
ER  -

