
%0 Journal Article
%A Brown, DJ 
%A Lan, S 
%A Mori, K 
%T Heterocyclic amplifiers of phleomycin. IV. Pyrimidinylpurines, phenylpyrimidines and related systems with basic side chains
%J Australian Journal of Chemistry
%D 1984/10/01
%V 37
%N 10
%P 2093-2101
%K 
%R https://doi.org/10.1071/CH9842093
%U https://www.publish.csiro.au/paper/CH9842093 
%X Syntheses of 4,5,6-triamino-2,4'-bipyrimidines and subsequent conversions into 6-amino-2-pyrimidinylpurine-8-thiones, and their S-dimethylaminoethyl derivatives, are described; routes to a series of cyclohexyl- and piperidino-pyrimidines bearing a sulfur-linked side chain, as well as to phenyl- and methyl-pyrimidines bearing two such side chains, are also described. As amplifiers of phleomycin in a bacterial screen, the above purines proved poor, the cyclohexyl- and piperidinopyrimidines showed medium activities, and the phenylpyrimidines with two side chains (but not the analogous methylpyrimidines) exhibited very high activities. 
