
%0 Journal Article
%A Marcuccio, SM 
%A Elix, JA 
%T Pyrazine chemistry. II. Reduction of 3,6-Dibenzylidenepiperazine-2,5-diones
%J Australian Journal of Chemistry
%D 1984/08/01
%V 37
%N 8
%P 1791-1794
%K 
%R https://doi.org/10.1071/CH9841791
%U https://www.publish.csiro.au/paper/CH9841791 
%X A reinvestigation of the reduction of 3,6-dibenzylidenepiperazine-2,5-dione (1) with zinc and acetic acid established that this reaction gave (Z)-6-benzyl-3-benzylidenepiperazine-2,5-dione (10). When a mixture of acetic acid and hydrochloric acid was used in the reduction, a mixture of trans- (12) and cis-3,6-dibenzylpiperazine-2,5-dione (5) was obtained. Direct catalytic reduction of 3,6-di(2-chloro- benzy1idene)piperazine-2,5-dione (2) to (±)-cis-3,6-di(2-chlorobenzyl)piperazine-2,5-dione (6) was also accomplished. 
