
%0 Journal Article
%A Brown, DJ 
%A Cowden, WB 
%A Lan, S 
%A Mori, K 
%T Heterocyclic amplifiers of phleomycin. I. Some pyrimidinylpurines, pyrimidinylpteridines and phenylpyrimidines
%J Australian Journal of Chemistry
%D 1984/01/01
%V 37
%N 1
%P 155-163
%K 
%R https://doi.org/10.1071/CH9840155
%U https://www.publish.csiro.au/paper/CH9840155 
%X Synthetic routes are described to 5,6-diamino-2,4'-bipyrimidin-4-ones and thence to 2-(pyrimidin-4'-yl)purines and 2-(pyrimidin-4'-yl)pteridines, some of which bear a sulfur- or nitrogen-linked basic side chain; also reported are routes to a series of phenyl- and diphenyl-pyrimidines, to each of which is attached a similar sulfur-, nitrogen-, or oxygen-linked side chain. Members of all the above systems show activity as amplifiers of phleomycin in a bacterial screen but the phenylpyrimidines with a sulfur-linked side chain are especially active. 
