
TY  - JOUR
A1  - Clarke, SI 
A1  - Kasum, B 
A1  - Prager, RH 
A1  - Ward, AD 
T1  - Central nervous system active compounds. XIII. The use of aminomethylene phthalides in the synthesis of phthalideisoquinoline alkaloids
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1983
VL  - 36
IS  - 12
SP  - 2493
EP  - 2498
KW  - 
UR  - https://doi.org/10.1071/CH9832493 
N2  - Dimethylaminomethyleneisobenzofuranones react with alkoxyphenylethylamines in aqueous acidic solution to give phthalide isoquinolines (tetrahydroisoquinolinylisobenzofuranones) in moderate yields. N-Methylation gives the naturally occurring phthalideisoquinoline alkaloids. A number of examples of this reaction sequence are reported, including the synthesis of (±)-cordrastine, (±)-corlumine and (±)-adlumine. 
ER  -

