
TY  - JOUR
A1  - Allan, RD 
A1  - Johnston, GAR 
A1  - Kazlauskas, R 
A1  - Tran, H 
T1  - Synthesis of analogues of GABA. IX. 5-(Aminomethyl)-3-hydroxyfuran-2(5H)-one
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1983
VL  - 36
IS  - 5
SP  - 977
EP  - 981
KW  - 
UR  - https://doi.org/10.1071/CH9830977 
N2  - 5-(Aminomethyl)-3-hydroxyfuran-2(5H)-one (4) has been synthesized as a GABA analogue in five steps from hex-3-enedioic acid, the enolic &#945;-keto group being introduced under mild conditions by means of a singlet oxygen cleavage of an enamino lactone. The compound showed negligible activity as a GABA agonist with respect to inhibition of [3H]GABA binding, uptake and trans amination in rat brain membranes 
ER  -

