
%0 Journal Article
%A Kirkpatrick, A 
%A Maclaren, JA 
%T Synthesis of 1,2,3,4-Tetrahydro-&#946;-carbolines
%J Australian Journal of Chemistry
%D 1983/04/01
%V 36
%N 4
%P 833-838
%K 
%R https://doi.org/10.1071/CH9830833
%U https://www.publish.csiro.au/paper/CH9830833 
%X 1,1-Disubstituted 1,2,3,4-tetrahydro-&#946;-carbolines are formed by the action of trifluoroacetic acid on enamines derived from tryptamine or tryptophan. With methanolic hydrogen chloride, either cyclization to the corresponding &#946;-carboline derivative, or acidolysis to regenerate the parent amine, occurs. The course of this reaction depends on the substitution pattern. Mixtures of products are not formed. Authentic phenacyl L-tryptophanate hydrochloride has been synthesized. 
