
TY  - JOUR
A1  - Cannon, JR 
A1  - Croft, KD 
A1  - Matsuki, Y 
A1  - Patrick, VA 
A1  - Toia, RF 
A1  - White, AH 
T1  - Crystal structure and absolute configuration of (+)-scandine hydrobromide
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1982
VL  - 35
IS  - 8
SP  - 1655
EP  - 1664
KW  - 
UR  - https://doi.org/10.1071/CH9821655 
N2  - The major alkaloid of a Fijian Melodinus sp. (family Apocynaceae) has been identified as (+)-scandine (1). The crystal structure and absolute configuration of the acetone solvate of (+)-scandine hydrobromide have been determined by X-ray diffraction; diffractometer data at 295 K were refined by block diagonal least squares to a residual of 0.037 (2657 'observed' reflections). Crystals of the hydrobromide are monoclinic, P21, a 9.496(3), b 14.561(5), c 9.339(3) Å, &#946; 115.39(2)º, Z 2. Although the cations of (+)-scandine hydrobromide and (+)-N-methylmeloscine bromide have the same skeleton and the same absolute configuration, they have different conformations; this appears to be due to the steric effect of the N-methyl group in the latter cation. 
ER  -

