
%0 Journal Article
%A Cannon, JR 
%A Croft, KD 
%A Matsuki, Y 
%A Patrick, VA 
%A Toia, RF 
%A White, AH 
%T Crystal structure and absolute configuration of (+)-scandine hydrobromide
%J Australian Journal of Chemistry
%D 1982/08/01
%V 35
%N 8
%P 1655-1664
%K 
%R https://doi.org/10.1071/CH9821655
%U https://www.publish.csiro.au/paper/CH9821655 
%X The major alkaloid of a Fijian Melodinus sp. (family Apocynaceae) has been identified as (+)-scandine (1). The crystal structure and absolute configuration of the acetone solvate of (+)-scandine hydrobromide have been determined by X-ray diffraction; diffractometer data at 295 K were refined by block diagonal least squares to a residual of 0.037 (2657 'observed' reflections). Crystals of the hydrobromide are monoclinic, P21, a 9.496(3), b 14.561(5), c 9.339(3) Å, &#946; 115.39(2)º, Z 2. Although the cations of (+)-scandine hydrobromide and (+)-N-methylmeloscine bromide have the same skeleton and the same absolute configuration, they have different conformations; this appears to be due to the steric effect of the N-methyl group in the latter cation. 
