
TY  - JOUR
A1  - Cowden, WB 
A1  - Jacobsen, NW 
A1  - Stunzi, H 
T1  - Pyrimidine N-oxides. V. Ionization constants of N-hydroxybarbiturates
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1982
VL  - 35
IS  - 6
SP  - 1251
EP  - 1253
KW  - 
UR  - https://doi.org/10.1071/CH9821251 
N2  - The ionization constants, pKa, of a number of N-hydroxy 5-substituted barbituric acids and their O-and N-alkylated derivatives are reported. For practical comparisons under physiological conditions, pKa values were also determined at I 0.15 M KNO3 and 37º for the clinically useful barbiturates metharbital, phenobarbital and veronal, and for their mono-N-hydroxy derivatives. The pKa values for N,N?-dihydroxyphenobarbital and the corresponding veronal were also measured. 
ER  -

