
TY  - JOUR
A1  - Brown, DJ 
A1  - Cowden, WB 
A1  - Strekowski, L 
T1  - Unfused heterobicycles as amplifiers of phleomycin. VI. Some thienyl- and thiazolyl-pyrimidines with strongly basic side chains
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1982
VL  - 35
IS  - 6
SP  - 1209
EP  - 1214
KW  - 
UR  - https://doi.org/10.1071/CH9821209 
N2  - 2-Chloro-4-(thien-2'-yl)pyrimidine (2a) and its thiazol-2'-yl analogue (2d) are prepared by condensation of 2-chloropyrimidine with thien-2-yl- and thiazol-2-yl-lithium, followed by oxidation of the dihydro intermediates. 4-Chloro-6-methyl-2-(thien-2'-yl)pyrimidine (3b),its 2-(2',4'-dimethylthiazol-5'-yl) analogue (3f) and the 2-(2'-methylthiazol-4'-yl) analogue (4b) are made from the corresponding pyrimidinones, which are available by primary synthesis. Each chloro compound is converted by nucleophilic displacement into its &#946;-dimethylaminoethylamino and &#946;-dimethylaminoethylthio derivatives, for which activities as amplifiers of phleomycin are reported and  discussed. 
ER  -

