
%0 Journal Article
%A Allan, RD 
%A Tran, H 
%T Synthesis of analogues of GABA. VII. (Z)- and (E)-4-Amino-3-(4-chlorophenyl)-but-2-enoic acids as unsaturated baclofen derivatives
%J Australian Journal of Chemistry
%D 1981/12/01
%V 34
%N 12
%P 2641-2645
%K 
%R https://doi.org/10.1071/CH9812641
%U https://www.publish.csiro.au/paper/CH9812641 
%X (Z)- and (E)-4-Amino-3-(4-chlorophenyl)but-2-enoic acids have been synthesized from 4-chloroacetophenone as conformationally restricted analogues of baclofen. The corresponding unsaturated lactam (4) has been catalytically reduced and hydrolysed to baclofen to demonstrate the suitability of (4) as a precursor for radiolabelled baclofen of high specific activity. 
