
TY  - JOUR
A1  - Brown, DJ 
A1  - Buttler, BB 
A1  - Cowden, WB 
A1  - Grigg, GW 
A1  - Kavulak, D 
A1  - Podger, DM 
T1  - Unfused heterobicycles as amplifiers of phleomycin. III. Thiazolylpyridines and bipyrimidines with strongly basic side chains
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1981
VL  - 34
IS  - 11
SP  - 2423
EP  - 2429
KW  - 
UR  - https://doi.org/10.1071/CH9812423 
N2  - Syntheses are described for 4-(thiazol-4'-yl)pyridines, each 2'-substituted by a dialkylaminoalkyl, dialkylaminoalkylthio or dialkylaminoalkylamino side chain; for 2- and 3-(thiazol-4'-yl)pyridines with a 2'-dimethylaminoethylthio substituent; for 4-(thiazol-2'-yl)pyridines with either a 4'- or a 5'-dialkylaminoalkylcarbamoyl substituent; and for some analogous compounds. The above and similarly substituted 2,4'-, 4,5'- and 5,5'-bipyrimidines have been screened for activity as amplifiers of phleomycin-G against Escherichia coli B by an improved in vitro procedure. The results are tabulated and discussed. 
ER  -

