
TY  - JOUR
A1  - Allan, RD 
A1  - Johnston, GAR 
A1  - Twitchin, B 
T1  - Synthesis of analogues of GABA. VI. Stereoisomers of <I>cis</I>-3-Aminocyclohexanecarboxylic acid
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1981
VL  - 34
IS  - 10
SP  - 2231
EP  - 2236
KW  - 
UR  - https://doi.org/10.1071/CH9812231 
N2  - The syntheses are described of (1R,3S)- and (1S,3R)-3-aminocyclohexanecarboxylic acids via unsaturated intermediates suitable for tritium labelling. The absolute stereochemistry was determined by an alternative synthesis of the (1R,3S) isomer from (R)-3-oxocyclohexanecarboxylic acid. The (1S,3R) isomer showed a similar potency to GABA as an inhibitor of the uptake of radioactive GABA by rat brain slices whereas the (1R,3S) isomer was at least 20 times less potent. 
ER  -

